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KMID : 0379520050210020179
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한국독성학회지
2005 Volume.21 No. 2 p.179 ~ p.186
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90-Day Inhalation Toxicity of Dimethylamine in F344 Rats
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Song Kyung-Seuk
Park Kun-Ho
Kim Jung-Hyon
Han Dong-Un
Chae Chan-Hee
Park Sung-Jin
Kim Hyun-Woo
Kim J.-S.
Park Jin-Hong
Eu Gook-Jong
Hua Jin
Cho Hyun-Sun
Hwang Soon-Kyung
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Abstract
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Dimethylamine (DMA) is a widely used commodity chemical with few toxicity data. Groups of 10 male and female F-344 rats were exposed by inhalation to 0, 5, 10, 20, 40 and 80 ppm of DMA for 6 hrs/day, 5 days/week for 90 days. The changes of body weight, organ weight, hematology, clinical chemistry, and histopathological changes were evaluated after the exposure. As the results, the body weight was significantly decreased at 80 ppm in male and female rats (p<0.05). The absolute lung weight showed no statistically significant changes in any group. In contrast, the relative lung weight significantly increased at 80 ppm in male and female rats (p<0.05). Erythrocytes, mean cell hemoglobin, leukocytes, neutrophil, and platelet numbers were significantly increased in male and female at 40 or 80 ppm of DMA (p<0.05, p<0.01). In addition, the serum values of total protein, urea nitrogen were increased in male and creatine kinase, total protein were increased in female rats at 40 or 80 ppm (p<0.05, p<0.01). Histopathological examinations of the male and female lung samples showed slight hyperplasia and congestion at 80 ppm. Taken together, our study revealed that maximum tolerated dose of DMA would be over 40 ppm.
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KEYWORD
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Inhalation, Dimethylamine, F344, Rats
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